Don’t get sucked into the idea that physics is the doyen of the leading edge of science. Physics just tackles the easy stuff to which the scientific method is best applicable. Physics tackles stuff that can be measured and observed with hard measurement yardsticks. That’s definitely the easy stuff.
Here are a few of the areas science has been wrestling with for centuries where very little progress has been made because … they are hard.
The Hard problem of consciousness. Hard problem of consciousness - Wikipedia
Sleep? What is it, and why do we need it? Why do some people need so much more than others? Why Do We Sleep?
Intelligence. What is intelligence? How do we measure it? How does one develop and enhance it? What are the limits of intelligence?
Economics. What is value and how do we measure it properly?
Soul. Is there a soul, a spirit, an afterlife, a world beyond the veil, with ghosts, angels, God?
Paranormal events, from levitation and telepathy to psychokinesis and prescience.
Time. What is it? Is it uni-directional? is the present infinitely small? Is the future infinite? is the past unchangeable? Is prescience possible? How is the Mandela effect explained?
Nature v Nurture. How do we explain our behaviour? Do we ever make Free Will choices? How much is genetics and how much is learned. Are we fated by our stars?
Abiogenesis. How did life begin? Did life begin on Earth? Why do we have Fermi’s paradox? https://en.wikipedia.org/wiki/Fermi_paradox we alone? Where is the other life in the universe?
Belief? What is belief and how does it work? How does the placebo effect work?
I would suggest that the limited progress that has been made in areas such as economics, behavioural psychology and genetics, artificial intelligence, and abiogenesis are far greater than the spectacular, but relatively easy, advances that have been made in physics and astronomy which are dealing with areas where measurement and observation are very straight forwards, and thus the scientific method applies very readily.
Physicists and technologists try and convince us that we live in a rational reality where science has or will find answers to everything, but a quick look at the many areas where science has made very little progress over centuries suggests to CK that we’ve just been tackling the easy bits, and most of reality is not amenable to study by the scientific method. Nevertheless the advances in such things as genetics, neuro-sciences and AI are casting real light on such questions as memory, consciousness, and intelligence.
These are the real frontiers of human understanding. And these also best exemplify the very real limits of human understanding. Not only is there so much we don’t know, but so many of those limits have barely moved in the last two millennia.
Hope this helps.